Dietary Directions Against Dementia Disorders

It has been established that dietary foods, fruits, vegetables, herbs, all contain phytochemicals in variable concentrations of monomer and polymeric-phenolic natural products that can be ideally directly absorbed or are transformed and metabolized by gut microbes into small compounds, many of which are neuro-available. However, their therapeutic efficacy, potency of their multi-purpose body-brain pro-health-activities including preventing peptide/protein misfolding diseases, antioxidant, anti-inflammatory functions to actively overcome neuropathologies, maintain and sustain brain cognition required for human health and against dementia disorders is unknown. Future neuro-nutritional studies will discover/tune the molecular mechanisms and metabolic processes of food consumption on body-brain and will determine and provide new strategies of how to optimize and select dietary constituents that may sustainably provide generic benefits for holistic health including neurochemical mechanisms, enabling neurons to better defend against insults and damage, and sustain mental fitness against AD, HD, PD, and ALS neurodegenerative diseases.