Business innovation has received much attention from Vietnamese practitioners and researchers. Yet, a collected account of studies on business innovation in Vietnam is still lacking. This introductory chapter sets a background and updates the current state of the art by introducing 16 chapters that address different aspects of business innovation in Vietnam. These chapters are selected from the “International conference on business innovation in a post-pandemic world”. The selected chapters emphasize two main themes: Digitalization and Smart logistics. As a result, the current chapter contributes an overview of business innovation in Vietnam. It also identifies various challenges and promotes approaches to address them.