The question of the inhabitation of cities is becoming one of the key issues of the 21st century as the number of people living in cities exceeds those in rural areas for the first time in history. This chapter addresses the conjunction of urban and interior in relation to the potential of interior design as a discipline that is no longer adequately defined by an architectural context but rather as a practice that is relational and attends to the relationships between people and environments. Emerging trajectories of interior design practice will be presented with the aim of positioning the criticality of contemporary interior design practice as a laboratory for the production of new urban interiors and interiorities.