Cardiac troponin detection using silicon photonic biosensor for the accurate and timely diagnosis and prognosis of acute myocardial infarction

We report a silicon Mach-Zehnder interferometer biosensor with an integrated microfluidic sample handling for an accurate and timely detection of cardiac troponin. The performance of the photonic biosensor was evaluated in terms of sensitivity, selectivity and reproducibility following the international clinical guidelines for acute myocardial infarction with the obtention of a complete cardiac troponin point-of-care test. We demonstrated that this biosensor was able to selectively detect cardiac troponin within 10 minutes in the ng/mL-μg/mL range with high reproducibility, achieving a limit of detection as low as 3 ng/mL in a direct assay.