This paper explores how the notion of mutuality can be an ethical driver for engaging participation in the co-design of future health practices and spaces. The context is the design and delivery of a co-design workshop to understand the future practices and ideal spaces for a university health education and research precinct. We report on how mutuality was employed as a framework across four distinct parts of an online co-design workshop. First, to develop the participatory toolkit; second, to engage the interdisciplinary facilitation team; third, to engage participants in envisioning future practices to take place in the precinct; and finally, to link the translation of future practices and values to spatial principles to drive architectural planning processes.