Study of change in enzymatic reaction under radiowaves/microwaves on lactic acid dehydrogenase and catalase at 2.1, 2.3 and 2.6 GHz

There is an increasing need to study and evaluate the impact of weak radiofrequency (RF) radiation at the cellular and molecular levels because of the worldwide increase in use of wireless telecommunication devices, mainly mobile phones, which has resulted in increased human exposure to RF fields. This study aims to improve our understanding of impact of low power RF/MW radiation (4G mobile network frequencies) on enzymatic reactions. The selected enzymes play crucial roles in the biological processes. L-Lactic dehydrogenase (LDH) is extensively present in blood cells and heart muscles, and is a marker of common injuries and disease. Catalase enzyme can be found in all living organisms, it is important for protecting a cell from oxidative damage by reactive oxygen species (ROS). This in vitro study evaluates the effects of low power RF/MW on kinetics of LDH and Catalase enzymes irradiated at the frequencies of 2.1, 2.3, and 2.6 GHz and two powers of 17 and -10 dBm using the commercial Transverse Electro-Magnetic (TEM) cell. Furthermore, changes in biological activity of Catalase enzyme irradiated at the particular frequency and different powers were also evaluated. The comparative analysis of experimental findings reveal that MW exposures at the particular studied parameters can induce changes in the enzymes' kinetics, which in turn lead to modulation of rate of change in corresponding reactions these enzymes catalyse.