Studying repressors-DNA interactions using the RRM approach and time-frequency analysis

A protein-DNA complex is characterized by three dimensional structures of the protein and DNA. In this article we have shown that by using two related computational techniques for analysis of DNA-protein interactions, i.e. Smoothed Pseudo Wigner Ville distribution (SPWV) and the Resonant Recognition Model (RRM), we can predict amino acids in the protein sequence which bind to DNA as well as the region of the repressor protein responsible for the recognition with DNA.