This paper demonstrates the structural optimization using Evolutionary Algorithms in a chalcogenide glass waveguide. Four features are taken into consideration while optimizing the waveguide structure, they include: single-mode, low dispersion, high nonlinearity and low loss. A set of waveguide structures which meet the design criteria are shown in the paper. The best structure enhances the nonlinear coefficient to 26000 /W/km at telecom wavelength. In this work, we demonstrate the methodology used to optimize waveguide as well as the procedure of conducting the experiment.