RMIT University
Browse

Alternations of maternal and cord plasma hemostasis in preeclampsia before and after delivery

journal contribution
posted on 2024-11-01, 10:10 authored by Yu Xiong, Shufeng Zhou, Rong Zhou, D Yang, Xu Zheng-Fang, Lou Yi-Ting, Guo Qing-sang, Hu Rong, Peng Ting, Ma Duan, Xiao-Tian Li
The aim of this study was to investigate the role of hemostatic factors in the pathogenesis of preeclampsia. Materials and Methods: Maternal and cord plasma concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPD, von willebrand factor (vWF), soluble P-selectin (sP-selectin), fibrinopeptide A (FPA), D-dimer, and anti· thrombin III (AT-III) were measured by enzyme-linked immunosorbent assay (ELISA) in 46 women with preeclampsia and 40 normotensive pregnant women before and after delivery. Results: The maternal plasma concentrations ofTF, vWF, and sP·selectin were higher, but lower concentrations ofTFPI, AT-III, and D·dimer were observed in women with preeclampsia compared to normotensive pregnant women before and after delivery. Compared with maternal plasma, fetal plasma concentrations of TF concentrations were increased significantly in both groups, whereas vWF, FPA, TFPI, AT-III, and D-dimer were decreased. Compared with normotensive pregnancy, fetal plasma concentrations ofTF were markedly increased in preeclampsia, accompanied with a higher vWF and a lower sP-selectin and D-dimer levels. Furthermore, fetal plasma TF concentrations were more significantly increased in women with high blood pressure and severe proteinuria. Conclusions: Imbalance in the coagulation/fibrinolysis equilibrium, especially alterations in the extrinsic pathway of coagulation and anticoagulation, may play an important role in the pathogenesis of preeclampsia. In addition, fetal alteration of TF may be involved in the pathogenesis of fetal complications of preeclampsia.

History

Journal

Hypertension in pregnancy

Volume

30

Issue

3

Start page

347

End page

358

Total pages

12

Publisher

Informa Healthcare

Place published

United States

Language

English

Copyright

© 2010 Informa Healthcare

Former Identifier

2006024915

Esploro creation date

2020-06-22

Fedora creation date

2011-05-19

Usage metrics

    Scholarly Works

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC