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Alternative synthesis of the anti-baldness compound RU58841

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posted on 2024-11-23, 09:00 authored by Matthew Leonard, Anthony Lingham, Julie Niere, Neale Jackson, Peter McKay, Helmut Hugel
RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography. This is achieved by stepwise construction of the hydantoin moiety around the amino group of 3- trifluoromethyl-4-cyanoaniline and ring closure to give a 2-nitropropane leaving group. On a small scale we achieved an overall yield of 33%.

History

Journal

RSC Advances

Volume

4

Issue

27

Start page

14143

End page

14148

Total pages

6

Publisher

R S C Publications

Place published

United Kingdom

Language

English

Copyright

This journal is © The Royal Society of Chemistry 2014

Former Identifier

2006045363

Esploro creation date

2020-06-22

Fedora creation date

2014-09-09

Open access

  • Yes

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