Bed rest or mobilization after rt-PA? A case-crossover study of factors influencing clinical decision making in stroke services

Background: Acute stroke management is a dynamic field. Treatment with recombinant tissue plasminogen activator is standard care in Australia, but there are no evidence-based practice guidelines about first out of bed activity (mobilization) after recombinant tissue plasminogen activator. Aims: To identify factors influencing clinicians' decisions to delay or allow mobilization. Methods: Case-crossover design. Using hypothetical case vignettes, we explored the factors that clinicians consider when deciding to first mobilize a patient after recombinant tissue plasminogen activator. Acute stroke physicians and nurses from Australian hospitals known to treat with recombinant tissue plasminogen activator participated. Information about hospital recombinant tissue plasminogen activator protocols and perceived benefits and harms of mobilization after recombinant tissue plasminogen activator were also captured. Results: Fifty-four clinicians, 52% senior nurses, and 48% senior physicians from all states of Australia participated.