Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373

Stokes, Leanne; Jiang, L-H; Alcaraz, L; Bent, J; Bowers, K; Fagura, M; Furber, M; Mortimore, M; Lawson, M; Theaker, J; Laurent, C; Braddock, M; Surprenant, A

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373

https://hdl.handle.net/10779/rmit.27456375

journal contribution

posted on 2024-11-01, 13:22 authored by Leanne Stokes, L-H Jiang, L Alcaraz, J Bent, K Bowers, M Fagura, M Furber, M Mortimore, M Lawson, J Theaker, C Laurent, M Braddock, A Surprenant

Background and purpose: The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified a novel set of cyclic imide compounds that inhibited P2X(7) receptor-mediated dye uptake in human macrophage THP-1 cells. In this study the actions and selectivity of one of these compounds, AZ11645373, were characterized.

History

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1.
DOI - Is published in 10.1038/sj.bjp.0706933
2.
ISSN - Is published in 00071188

Journal

British Journal of Pharmacology

Volume

149

Issue

7

Start page

880

End page

887

Total pages

8

Publisher

John Wiley & Sons

Place published

United Kingdom

Language

English

Copyright

Former Identifier

2006041216

Esploro creation date

2020-06-22

Fedora creation date

2015-09-29

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Keywords

cyclic imides heterologous expression purine receptors receptor antagonist

Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373

History

Related Materials

Journal

Volume

Issue

Start page

End page

Total pages

Publisher

Place published

Language

Copyright

Former Identifier

Esploro creation date

Fedora creation date

Usage metrics

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Keywords

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