Degradable, surfactant-free, monodisperse polymer-encapsulated emulsions as anticancer drug carriers

Degradable, surfactant- free, micrometer- to sub-micrometer-sized polymer-encapsulated emulsions loaded with lipophilic drugs (doxorubicin and 5-fluorouracil) are prepared. In vitro drug-release studies demonstrate controlled release under redox conditions and incubation with human colorectal cancer cells triggers cell death with greater efficiency (10 6 fold) than the free drug.