Design of endoperoxides with anti-Candida activity

Avery, Thomas; Macreadie, Peter; Greatrex, B; Robinson, Tony; Taylor, Dennis; Macreadie, Ian

Design of endoperoxides with anti-Candida activity

journal contribution

posted on 2024-11-01, 09:02 authored by Thomas Avery, Peter Macreadie, B Greatrex, Tony Robinson, Dennis Taylor, Ian MacreadieIan Macreadie

Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

History

Related Materials

1.
DOI - Is published in 10.1016/j.bmc.2006.10.021
2.
ISSN - Is published in 09680896

Journal

Bioorganic & Medicinal Chemistry

Volume

15

Issue

1

Start page

36

End page

42

Total pages

7

Publisher

Pergamon

Place published

United Kingdom

Language

English

Copyright

Former Identifier

2006023719

Esploro creation date

2020-06-22

Fedora creation date

2011-11-14

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Keywords

Antifungal Artemisinin Candida Endoperoxide Growth inhibition Hemolytic activity

Design of endoperoxides with anti-Candida activity

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Related Materials

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