The effect of the reactant particle size on the self-propagating high-temperature synthesis (SHS) reaction behaviors in the Ni-Ti-B4 C system was investigated in the present study. The B4 C particle size has a significant effect on the ignition behavior and combustion wave velocity, while Ti and Ni particle sizes have only a limited influence. Increasing the B4 C particle size retards the reaction initiation and remarkably lowers the combustion velocity and combustion temperature. The reaction products are mainly dependent on the B4 C particle size. Nevertheless, decreasing Ni and Ti particle sizes is in favor of perfect products consisting of only TiC, TiB2, and Ni phases.