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Endogenous lung stem cells for lung regeneration

journal contribution
posted on 2024-11-02, 10:48 authored by Jonathan McQualterJonathan McQualter
Introduction: Lifelong maintenance of a healthy lung requires resident stem cells to proliferate according to tissue requirements. Once thought to be a quiescent tissue, evolving views of the complex differentiation landscape of lung stem and progenitor cells have broad implications for our understanding of how the lung is maintained, as well as the development of new therapies for promoting endogenous regeneration in lung disease. Areas covered: This review collates a large body of research relating to the hierarchical organization of epithelial stem cells in the adult lung and their role in tissue homeostasis and regeneration after injury. To identify relevant studies, PubMed was queried using one or a combination of the terms 'lung', 'airway', 'alveoli', 'stem cells', 'progenitor', 'repair' and 'regeneration'. Expert opinion: This review discusses how new technologies and injury models have challenged the demarcations between stem and progenitor cell populations.

History

Journal

Expert Opinion on Biological Therapy

Volume

19

Issue

6

Start page

539

End page

546

Total pages

8

Publisher

Taylor & Francis

Place published

United Kingdom

Language

English

Copyright

© 2019 Informa UK Limited, trading as Taylor & Francis Group

Former Identifier

2006090776

Esploro creation date

2020-06-22

Fedora creation date

2019-10-23

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