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Hierarchical Self-Assembly of Peptides and its Applications in Bionanotechnology

journal contribution
posted on 2024-11-02, 13:05 authored by Barbara Gerbelli, Sandra Vassiliades, Jose Rojas, Juliane Pelin, Francesca CavalieriFrancesca Cavalieri
Self-assembled structures obtained from organic molecules have shown great potential for applications in a wide range of domains. In this context, short peptides prove to be a particularly versatile class of organic building blocks for self-assembled materials. These species afford the biocompatibility and polymorphic richness typical of proteins while allowing synthetic availability and robustness typical of smaller molecules. At the nano-to-mesoscale, the architectures obtained from peptide units exhibit stability and a large variety of morphologies, the most common of which are nanotubes, nanoribbons, and nanowires. This review describes the formation of peptide-based self-assembled structures triggered by different stimuli (e.g., ionic strength, pH, and polarity), and the interactions that drive the assembling processes. It is surveyed how judicious molecular design is exploited to impart favourable assembling properties to afford systems with desired characteristics. A large body of literature provides the experimental and in silico data to predict self-assembly in a given peptide system and obtain different supramolecular organizations for applications in a wide range of fields, from transport to sensing, from catalysis to drug delivery and tissue regeneration.

History

Journal

Macromolecular Chemistry and Physics

Volume

220

Number

1900085

Issue

14

Start page

1

End page

22

Total pages

22

Publisher

Wiley- VCH Verlag GmbH & Co. KGaA

Place published

Germany

Language

English

Copyright

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Former Identifier

2006098351

Esploro creation date

2020-06-22

Fedora creation date

2020-05-05

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