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Involvement of the autophagy-er stress axis in high fat/carbohydrate diet-induced nonalcoholic fatty liver disease

journal contribution
posted on 2024-11-02, 16:33 authored by Xiu Zhou, Sherouk Fouda, Dongli Li, Kun Zhang, Jiming Ye
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), and even further to liver cirrhosis or liver cancer. Overconsumption of high fat and/or carbohydrate are among the most common lifestyle factors that drive the development and progression of NAFLD. This review evaluates recent reports on the involvement of autophagy and endoplasmic reticulum (ER) stress in the pathogenesis of NAFLD. Here, we reveal a mechanism of an intrinsically linked axis of impaired autophagy and unresolved ER stress that mediates the development and progression of NAFLD resulting from the overconsumption of high fat and/or carbohydrate.

History

Journal

Nutrients

Volume

12

Number

2626

Issue

9

Start page

1

End page

12

Total pages

12

Publisher

MDPIAG

Place published

Switzerland

Language

English

Copyright

© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Former Identifier

2006105608

Esploro creation date

2021-04-21

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