Oxidative Copper-Catalyzed Regioselective Trifluoromethylation of Fused Imidazo[1,5-a]-N-heteroarenes using Langlois Reagent

A simple, mild, and efficient oxidative copper-catalyzed regioselective trifluoromethylation of imidazo[1,5-a]-N-heteroarenes have been developed using Langlois, (NaSO2CF3) reagent as CF3 source. This method gives biologically relevant trifluoromethylated fused imidazoles in moderate to good yields with good functional group tolerance. The key features of the reaction are mild conditions, short reaction time, and room temperature reaction.