Chemical profiling of the southern Australian marine alga Laurencia elata (Rhodomelaceae) employing on-flow and stop-flow HPLC-NMR methodology followed by off-line chemical investigations resulted in the isolation of two C 16 chamigrenes, cycloelatanene A and B together with three previously reported sesquiterpenes, (3Z)-chlorofucin, pacifenol and elatenyne. The chemical structures were elucidated via detailed spectroscopic analyses.