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Quantifying the advantage of photon correlation microscopy using arrays of single-photon detectors

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journal contribution
posted on 2025-10-23, 03:55 authored by Jaret Vasquez-Lozano, Qiang Sun, Shuo Li, Andrew GreentreeAndrew Greentree
<p dir="ltr">Correlation microscopy is an emerging technique for improving optical resolution. By taking advantage of the photon statistics from single-photon fluorophores, more information about the emitters (including number and location) is obtained compared with classical microscopy. Although it is known that the resolution can be improved by increasing detector numbers, as well as using photon correlations, the quantitative relationship between these two approaches is not immediately clear. Here we explore widefield photon correlation microscopy using arrays of single-photon detectors. We explicitly compare the use of <i>N</i> detectors used in photon counting mode vs <i>N</i>/2 detectors used to measure photon correlations. i.e., where there are <i>N</i>/2 Hanbury Brown and Twiss systems, using the same <i>N</i> detectors, on randomly generated two-emitter systems and triangular three-emitter systems. We find regimes where <i>N</i>/2 Hanbury Brown and Twiss detectors provide improved localisation compared to <i>N</i> photon counting detectors, as a function of emitter position and number of photons sampled.</p>

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  1. 1.
    URL - Is published in https://doi.org/10.1364/oe.568719
  2. 2.
    DOI - Is published in DOI: 10.1364/oe.568719
  3. 3.
    ISSN - Is published in 1094-4087 (Optics Express)

Journal

Optics Express

Volume

33

Issue

21

Start page

44858

End page

44877

Total pages

20

Publisher

Optica Publishing Group

Language

en

Copyright

© 2025 Optica Publishing Group under the terms of the Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for noncommercial purposes and appropriate attribution is maintained. All other rights are reserved.

Open access

  • Yes