Reviving Fertility: Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

<p dir="ltr">Background </p><p dir="ltr">Male infertility poses a growing challenge to the healthcare system, with its prevalence on the rise. Unhealthy lifestyle, food, and addictions such as smoking, alcoholism, etc. accelerate the occurrence. While several approaches are being investigated to prevent and treat this condition, each therapeutic approach has its drawbacks. Traditional medications continue to play a crucial role in the healthcare system. In recent years, there has been a shift towards determining the efficacy of phytochemicals (or, herbal drugs) as remedies. </p><p dir="ltr">Objective </p><p dir="ltr">To evaluate the effect of various herbs, plant, metabolites, or a part of plant in management of non-genetic male infertility. </p><p dir="ltr">Methods </p><p dir="ltr">The male infertility-associated keywords were searched in PubMed, excluding those non-English writen papers. A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic evaluation. </p><p dir="ltr">Results </p><p dir="ltr">The manuscript focuses on individual herbal drug components, their active ingredients, their role in improving the condition and quality of life, and decreasing the prevalence of male infertility. </p><p dir="ltr">Conclusion </p><p dir="ltr">Herbal medicinal plants show promising outcomes to treat male infertility. Herbal alternatives are appealing and have regained popularity. The future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.</p>