Crashes involving heavy trucks and vulnerable road users are a major road safety concern because of the higher likelihood of fatal and serious injury. This research identified the socioeconomic characteristics affecting injury severity in collisions involving trucks and vulnerable road users. Specifically, the influences of the sociodemographic characteristics of road users, the neighborhoods where the road users live, and where the crashes occur were explored using the random parameter ordered logit model. This study found that the age and gender of vulnerable road users involved; the age, language, occupation, religion, and income of the person’s residency neighborhood; and the age, occupation, religion, and income of the crash neighborhood had a significant influence on injury severity.