High Volume Fly Ash (HVFA) concrete has been shown to be a viable alternative construction material to Portland cement concrete to improve sustainability and durability. In addition, nano silica been found to be a significant contributor towards increasing the early age strength and the durability properties of HVFA concrete. This study reports an investigating of the resistance of HVFA concrete with 65% and 80% replacement of cement, with nano silica and hydrated lime, exposed to acid and sulphate solutions over a 2-year period. The change in physical appearance, mass and length was monitored, together with detailed mechanical, chemical and microscopy analysis at 12 and 24 months. The results indicate that the HVFA concrete mixes provided enhanced resistance compared to Portland cement concrete. The HVFA 80% cement replacement performed better in acid media while, the HVFA concrete mix with 65% cement replacement was superior in sulphate media.