The potential combination of aunps with kilovoltage synchrotron radiation: radiobiological evaluation

Optimum and selective approaches to treat cancer become crucial aspects in radiotherapy. The promising application radiosensitizer such as gold nanoparticles (AuNPs) that capable to be internalize and moving in the vicinity of the nucleolus environment could potentially be a suitable technique to achieve conformality in radiotherapy. AuNPs in combination with kilovoltage synchrotron beams is predicted to give an impeccable damage to tumor through the photoelectric effects and hence contribute the radiosensitization mechanisms. However minimal understanding in the radiobiological and physical impacts might hinder this application from clinical trials. In this study, kilovoltage synchrotron beam of energy 70 and 81.5 keV combined with AuNPs were tested on P815 with and without AuNPs. Cell viability assay were conducted and cell survival were calculated. Cell survival curves generated from radiobiological models were fitted to the experimental cell survival data. in this study. Sensitization enhancement ratio (SER) was used to measure the radiosensitization effects. The effects of AuNPs are obvious especially for 70 keV beam energy with highest SER of 2.32 model cell survival curves. Meanwhile, LQ model depicted lower SER of 1.25 and 1.24 for 70 and 81.5 keV respectively. It is concluded, the combination of AuNPs and synchrotron beam irradiation may give optimum treatment towards targeted tumor with suitable radiobiological model to fully evaluate and understand the potential towards clinical breakthrough.