Development in the design and thermal performance of the loop heat pipes (LHPs) demands the corresponding improvement in the theoretical modeling capabilities of these devices. In this paper, mathematical model for assessing the thermal performance of the miniature LHPs (mLHPs) on the basis of the operating temperature and thermal resistance of the loop has been discussed in detail. In order to validate the theoretical model, a mLHP with the flat disk shaped evaporator, 30 mm in diameter and 10 mm thick, was developed and tested with nickel and copper wick structure. By comparison with experimental results, it was found that the theoretical model was able to predict the evaporator temperature and loop thermal resistance very well and within the uncertainties imposed by the underlying assumptions. The mathematical model can be used to validate the design of the mLHP and verify whether the proposed design is consistent with the maximum heat load capacity required for the intended application. In addition to this, the model can assists in understanding and refining the outcomes of the experimental studies.