Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart
journal contribution
posted on 2024-11-01, 08:45 authored by Spencer Williams, Colleen Thomas, Mirna Boujaoude, Carlie Gannon, Shannon Zanatta, Bevyn Jarrott, Clive May, Owen WoodmanPhosphate and hemiadipate derivatives of cardioprotective flavonols are water soluble prodrugs that
release superoxide scavenging and vasorelaxant parent drugs. These prodrugs protected against
ischaemia/reperfusion injury in two distinct animal models, rat hindlimb and sheep heart, and are thus
promising small molecule therapeutics for cardiovascular disease.
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Journal
MedChemCommVolume
2Issue
4Start page
321End page
324Total pages
4Publisher
Royal Society of ChemistryPlace published
United KingdomLanguage
EnglishCopyright
© The Royal Society of Chemistry 2011Former Identifier
2006026310Esploro creation date
2020-06-22Fedora creation date
2015-01-16Usage metrics
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3',4' dibenzyloxyflavonol4' benzyloxyflavonolOvis ariesRattusanimal experimentanimal modelanimal tissueantioxidant activityarticlecalcium ionconcentration responsecontrolled studydrug structuredrug synthesisfemaleflavonol derivativeheart muscle ischemiaheart protectionhindlimbhydrophilicitylactate dehydrogenaselimb ischemianonhumanpriority journalratreperfusion injurysheepthoracic aortaunclassified drugvasodilatation, Animalia
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