ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Poddar, Arpita; Pyreddy, Suneela; Carraro, Francesco; Dhakal, Sudip; Rassell, Andrea; Field, Matthew; Telukutla, Srinivasa Reddy; Falcaro, Paolo; Doherty, Cara; Shukla, Ravi

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

journal contribution

posted on 2024-11-02, 16:05 authored by Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew Field, Srinivasa Reddy TelukutlaSrinivasa Reddy Telukutla, Paolo Falcaro, Cara Doherty, Ravi ShuklaRavi Shukla

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

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1.
DOI - Is published in 10.1039/d0cc06241c
2.
ISSN - Is published in 13597345

Journal

Chemical Communications

Volume

56

Issue

98

Start page

15406

End page

15409

Total pages

4

Publisher

Royal Society of Chemistry

Place published

United Kingdom

Language

English

Copyright

Former Identifier

2006104468

Esploro creation date

2021-12-03

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ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

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