Minimizing the Side Effects of Juxtamembrane Mimic Peptide 2 (JM2) on Healthy Cells Through Surface Acoustic Waves (SAW)

The Juxtamembrane mimic 2 (JM2) peptide has been shown to be highly effective on killing cancer cells, yet they seem to be most rewarding at higher concentrations. At higher concentrations of JM2, healthy cells also die, which threatens the potential of using JM2 as an anticancer drug. Surface acoustic waves, or SAW, is high frequency acoustic nano-vibrations made on a piezoelectric crystal. These waves have been used in a plethora of ways and is currently being further researched for its use in lab-on-chip (amongst other things). Researchers have previously used SAW for intracellular delivery, which shows an enhanced intracellular delivery of nanoparticles without affecting cell viability of HEK293T cells (kidney cells). Using this idea, we plan to further expand on this paper and attempt to reduce the effective concentration of JM2 against cancer cells, while reducing the impact on healthy cells.